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KMID : 0606920110190020181
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Biomolecules & Therapeutics
2011 Volume.19 No. 2 p.181 ~ p.186
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Protective Effect of Chlorogenic Acid against Aβ-Induced Neurotoxicity
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Lee Chan-Woo
Won Tae-Joon
Kim Hak-Rim
Lee Dong-Ho
Hwang Kwang-Woo
Park So-Young
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Abstract
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Beta-amyloid (Aβ) is considered as one of the major causes of Alzheimer’s disease. This study examined the neuroprotective effects of chlorogenic acid, a naturally occurring polyphenol which is distributed widely in plants, fruits and vegetables, against Aβ-induced toxicity. Aβ decreased signifi cantly the viability of PC12 cells. This was accompanied by an increase in the intracellular calcium levels and cleaved caspase-3. In addition, Aβ induced an increase in Bax, and a decrease in Bcl-2 compared to the controls. However, a pre-treatment with chlorogenic acid rescued the PC12 cells from Aβ by attenuating the elevated intracellular calcium levels and reducing the levels of the apoptosis related proteins, including caspase-3, Bcl-2 and Bax. These results suggest that the protective effects of chlorogenic acid are, at least in parts, by attenuating the intracellular calcium infl ux and reducing apoptosis induced by Aβ.
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KEYWORD
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Chlorogenic acid, Beta-amyloid, Calcium influx, Apoptosis, PC12 cells
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